​Development and Function of Gamma Delta T Cells
The Boyson lab is focused on understanding the factors that regulate the development and function of gamma delta T cells. To address these questions, we use single-cell analysis tools such as high-dimensional flow cytometry, single-cell RNAseq with V(D)J profiling, and scATACseq to assess gamma delta T cell phenotype and function in genetically-engineered mouse models. 

Gamma Delta T Cell Development and Function


​While all T cells develop in the thymus, only some develop into innate-like T cells. We are interested in understanding the signals and transcriptional programs that prompt developing T cells to acquire innate-like properties. Currently, we are focusing on the contributions of a signaling pathway, called the SLAM/SAP signaling in the development and function of innate-like gamma delta T cells. 

Gamma Delta T cells in Cancer

​Gamma delta T cells have long been known to efficiently lyse tumor cells. More recently, work from several groups has shown that IL-17-producing gamma delta T cells can actually promote tumor growth and metastasis. We are interested in understanding how the tumor microenvironment promotes the function of anti-tumor vs. pro-tumor gamma delta T cells. To address this question, we are investigating the phenotype and function of gamma delta T cells in an inducible model of lung adenocarcinoma.

Maternal Inflammation and Prenatal T Cell Development

One very unusual feature of gamma delta T cell development is that certain specific subsets and functions are programmed in the embryonic and neonatal thymus. This restricted period of thymic developmental programming suggests the possibility that disrupted development at this stage could have long-term consequences for gamma delta T cell development and function. We are interested in understanding the impact that inflammatory events during pregnancy has on embryonic/fetal gamma delta T cell development and whether these alterations persist in the adult offspring.
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